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ROS production has been shown to activate AMPK, inducing mitophagy and promoting M2 macrophage polarization in monocytes [263]
While they do not contain nicotine, they still produce smoke, which can irritate the lungs and respiratory system
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[24] There is a reference to tobacco in a Persian poem dating from before 1536, but because of the lack of any corroborating sources, the authenticity of the source has been questioned
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